72% reduced risk of tumor spread with exercise

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A new study shows that high-intensity exercise increases glucose consumption in internal organs, which may reduce the energy needed for tumors to spread. Solskin / Getty Images
  • A recent study It was found that high-intensity aerobic exercise increases glucose consumption in the internal organs.
  • The researchers believe that this connection reduces the availability of energy needed for the growth of tumors.
  • Using data from a prospective study, the researchers found 72% fewer metastatic cancers in participants who regularly participate in high-intensity aerobic activities.
  • In another study involving mice, researchers found that aerobic activity reduced the development of metastatic tumors in the lymph nodes, lungs, and liver.

Metastatic cancer is cancer that has spread from where it started to another part of the body.

The researchers behind a Study 2022 It was estimated that 623,405 individuals in the United States were living with breast, prostate, lung, colorectal, bladder, or metastatic melanoma in 2018.

While working with other researchers, Prof. Carmit Levy, Ph.D., Associate Professor of Human Molecular Genetics and Biochemistry at Tel Aviv University, became interested in how resistant muscles are to metastatic cancer.

This work led to a new study from Tel Aviv University that was recently published in cancer researchwhich suggests that people may be able to reduce their risk of metastatic cancer by regularly engaging in high-intensity aerobic exercise.

“From [being curious] “Arounding muscles, we ended up examining physical activity,” said Professor Levy. Medical news today. “We said, ‘Well, there’s something about muscle activity that might be protecting this organ from being a common site of metastasis for all kinds of cancers.'” “

Through their work, the researchers identified the mechanism underlying the protective effect of exercise. They found that physical activity increases the consumption of glucose by the internal organs, which means Less energy is available to the tumor.

Erica Reese BoniaPhD, MPH, senior principal scientist in epidemiology and behavioral research at the American Cancer Society, not involved in the study, described the mechanism behind MNT:

Simply put, exercise “reprograms” our organs to require more nutrients. At the same time, healthy organs of exercisers can more easily outpace cancer cells (particularly melanoma cells, in the case of this study) in terms of nutrients. This leaves fewer of the nutrients available to the tumor for use in growth.”

For the study, Professor Levy and Dr. Yiftah Gepner, senior lecturer in the School of Public Health at Tel Aviv University, combined data from a prospective study conducted by The Israeli Center for Disease Control and the Nutrition Department of the Israeli Ministry of Health.

They examined 2,734 men and women selected from the general Israeli population who were originally cancer-free and between the ages of 25 and 64 were examined before and after running.

Participants answered two physical activity questionnaires about vigorous and moderate activity that lasted for 10 minutes. They have been followed for 20 years.

In addition, the researchers recruited 14 male and female runners, ages 25 to 45.

Participants were excluded for being smokers, taking prescription medications, or having a history of chronic lung, heart, metabolic, or bone disease.

They were also asked to avoid caffeine for 12 hours, food for 3 hours, and strenuous physical activity for at least 24 hours before arriving in the lab for testing.

Participants ran for 30 minutes on a treadmill at the highest speed they could manage for the duration.

Next, the researchers combined ventilators and metabolic measurements using breath-by-breath analysis and monitored the participants’ heart rates using a chest strap. They collected blood from the participants before and after the exercise.

In another study, the researchers used an animal model where mice were subjected to exercise regimens.

They chose female mice because they showed an increased metabolic response to exercise compared to males.

One group of mice was used as a control. The other underwent a treadmill training protocol. Mice exercise every day. Gradually, the researchers increased the duration and intensity of the exercise. This went on for 8 weeks.

Then some mice were injected with melanoma cells. After 4 days of recovery, the researchers subjected these mice again to regular exercise on a treadmill for an additional 4 weeks.

Subsequently, the researchers harvested the lungs, lymph nodes, liver, and skeletal muscles of both sedentary mice and mice that had undergone exercise. my protein and ex vivo metabolic capacity analyzes.

“We took organs that usually host metastasis,” Levy said. MNT.

And we said: let’s dissect these organs and see how these organs behave after long-term physical activity.

Protein analysis of the blood of routinely active participants showed increased carbohydrate utilization after exercise.

Data from the prospective study showed that exercise before cancer had a modest effect on prognosis for indolent cancer.

However, exercise “significantly reduced the likelihood of developing highly metastatic cancer,” according to the researchers.

Among the participants studied, those who reported regular, high-intensity aerobic exercise had 72% fewer metastatic cancers than sedentary participants.

In the mouse study, the researchers found that mice that underwent exercise before being injected with cancer cells were “significantly protected” from metastasis to distant organs.

Ex vivo and protein metabolic capacity analyzes of rat organs showed that exercise stimulates catabolic processes, glucose uptake, mitochondrial activity, and GLUT expression.

When the researchers looked at the organs of the mice, they discovered that long-term physical activity altered the muscles (increased muscle mass) and altered the organs.

We discovered that internal organs such as the lymph nodes, such as the lung, such as the liver, are those organs that usually host cancer [are] It changes when there is chronic physical activity,” Levy said MNT.

“They have changed [the] Meaning they become super metabolic. And when I say super metabolic, I mean their demand for glucose and the demand for their mitochondria is increasing. [and] Their glucose uptake increases. They have become like members of superheroes.”

Researchers believe that when cancer tries to attack these organs, it is losing the battle.

Adrian Christian, chief of cancer rehabilitation at the Miami Cancer Institute, part of Baptist Health of South Florida, explained. MNT Through this study, the researchers showed that “exercise leads to changes in the microenvironment of cancer cells that make them unfavorable for their growth when non-cancerous cells compete for nutrients.”

In future research, Levy said MNTResearchers can look at whether exercise needs to be of a high intensity to gain the protective effect.

“What we were studying here was aerobic,” Levy noted. “I’m not saying Pilates doesn’t do the same thing. I just don’t know because we haven’t taught others [types] of physical activity.”

The researchers who worked on this study are also interested in looking at how exercise may affect people who already have cancer, as well as how much the protective effect of exercise may last when people stop exercising regularly.

“How long does the body remember? We don’t know,” Levy said.

The authors of this study are currently looking at how physical activity affects brain metastases.

According to Dr. Christian, more research is needed on how exercise affects the metastasis of common cancers, such as breast, prostate, colorectal, lung and gynecologic cancers.

“Which cancers are most sensitive to exercise as an intervention to reduce the spread of metastasis,” said Dr. Christian.